Top Definition
The title is a Southern expression meaning at my wit's end.
When things are going so bad you could lose your faith.

Also a fabulous R.E.M. song.
Between the tight job market and my whiny kids I'm loosing my religion.
#discouraged #bumed out #depressed #lost hope #disheartened
od uživatele pfeifferpack 08. duben 2011
Best fucking black metal song ever. But only Graveworm's version, though.
I listened to Loosing my Religion over a dozen times last night.
#best #fucking #song #ever #i tell you
od uživatele Paracetamol 500mg 30. září 2006
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