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1.
Do something. Usually with purpose.
You wanna fight? Let's do it up bitch!
od uživatele connick 04. Březen 2003
 
2.
Meaning go for it.

Jim: I'm tired, I might go lie down.
Dani: do it up.
od uživatele duhani 20. Únor 2009
 
3.
A somewhat half-hearted verbal command used when a person agrees with another person's inclination to perform a task. The phrase is usually said hastily, and can also be stylized by stretching the first or the last vowel, depending on preference.
"Yayuhh, im tryin to get with herrr."
"doitup man."

"I should heat up those nachos."
"Good1 doituuup."
od uživatele slazer 22. Listopad 2007
 
4.
The act of being boss and getting something done, usually in a very cool or gangsta way.
Bitch, shut yo fat-ass mouth! Let's Do It Up, skank!
od uživatele LuLuBee 07. Listopad 2010