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1.
A particularly unpleasant hangover.
"Last night was great, but I have the worst case of the irish flu today."
od uživatele Melissa 10. Červenec 2004
 
2.
A hangover, usually involving whiskey; may be mild or severe
"I’ve still got a touch of the Irish flu."

"The Irish flu?"

"Also known as a hangover."

(from "A Nose for Murder" by Lee Charles Kelley
od uživatele Lee Charles Kelley 06. Duben 2005
 
3.
The ailment one suffers on March 18th after properlyly celebrating St. Patrick's Day. Anyone of Irish descent may also use the term to denote a hangover on any day of the year.
Seamus: Ugh, I was out drinking Guinness until the wee hours. I think I'll call in with the Irish Flu today.
od uživatele robbie vienna 17. Březen 2009